In laboratory animals, no anticholinergic or alpha1-adrenergic blocking effects were observed.Moreover, no sedative or other central nervous system effects were observed.Common side effects are thickening of bronchial secretions, nausea, drowsiness, and headache.Therapeutics A potent, antiinflammatory H1-receptor antagonist used for respiratory allergies; it has little CNS reactivity or cardiotoxicity and doesn't interact with other medicines. Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor.Radiolabeled tissue distribution studies in rats indicated that fexofenadine does not cross the blood-brain barrier.Dosage - Oral: Children 6-11 years: 30 mg twice daily Children /= 6 years and Adults: 10 mg once daily Elderly: Peak plasma levels are increased; elimination half-life is slightly increased; specific dosing adjustments are not available Dosage adjustment in renal impairment: Clcr /= 6 years and Adults: 10 mg every other day Supplied Syrup (Claritin®): 1 mg/m L (120 m L) [contains sodium benzoate; fruit flavor] Tablet (Alavert™, Claritin®, Claritin® Hives Relief; Tavist® ND): 10 mg Tablet, rapidly-disintegrating: 10 mg Alavert™: 10 mg [contains phenylalanine 8.4 mg/tablet] Claritin® Redi Tabs®: 10 mg [mint flavor] Dimetapp® Children's ND: 10 mg [contains phenylalanine 8.4 mg/tablet] (pseudoephedrine 120mg fexofenadine 60mg).A dose of 60 mg once daily is recommended as the starting dose in patients with decreased renal function Mechanism of Action Fexofenadine hydrochloride, the major active metabolite of terfenadine, is an antihistamine with selective peripheral H1-receptor antagonist activity.
If a sedating antihistamine must be prescribed, its sedative effects should be thoroughly considered before choosing the drug.
Dosing:: one tablet twice daily for adults and children 12 years of age and older (should be taken on an empty stomach).
A dose of one tablet once daily is recommended as the starting dose in patients with decreased renal function.
adverse effects Life-threatening effects include hemolytic anemia, thrombocytopenia, leukopenia, agranulocytosis, pancytopenia, and dysrhythmias (rare).
Other serious adverse effects include urinary retention, impotence, diarrhea, vomiting, sedation, confusion, blurred vision, tremors, hypotension, palpitations, bradycardia, and tachycardia.